Job Description

ATTENTION MILITARY AFFILIATED JOB SEEKERS - Our organization works with partner companies to source qualified talent for their open roles. The following position is available to Veterans, Transitioning Military, National Guard and Reserve Members, Military Spouses, Wounded Warriors, and their Caregivers. If you have the required skill set, education requirements, and experience, please click the submit button and follow the next steps. Unless specifically stated otherwise, this role is "On-Site" at the location detailed in the job post. Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area. Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities. Position Summary: This is an exciting opportunity to develop and execute on a strategy to identify and advance our understanding of cancer immunology and tumor cell extrinsic targets by applying functional genomics to interrogate patient-relevant disease models (cell lines, organoids (PDO), PDX). The successful applicant will lead a team to use cutting-edge techniques to generate biological, mechanistic, and structural insights that support target rationale. The candidate will be expected to collaborate effectively with colleagues within Discovery Oncology and across the BMS enterprise, including Drug Discovery, Translational Research, Informatics and Predictive Sciences, and the Discovery and Development Sciences groups. Position Responsibilities: In the role as a Principal Scientist within Discovery BioSciences, the ideal candidate: Will be responsible for the discovery of next-generation oncology biotherapeutic targets (eg. ADCs, multispecifics, and TCEs) utilizing molecular biology and genome engineering techniques in disease relevant pre-clinical models. The role requires extensive knowledge in how to functionally interrogate biotherapeutics-based mechanisms and modalities including screen conceptualization, design, and execution. Effective management skills with a track record of leading effective teams. Proven ability to strategize, develop, and articulate concepts. Work across teams, externally interface, with good communication skills. Strong biology skills with experience using a wide range of cellular and molecular biology techniques, cell culture and manipulation of complex cellular model systems (organoid, immune and stromal cell co-culture, and cancer cells), flow cytometry, qPCR, cell proliferation assays, generating reporter assays, molecular cloning techniques, western blotting, immunoprecipitation, ELISA. Strong experience developing and applying state-of-the-art gene perturbation methods (siRNA/shRNA knockdown and CRISPR-mediated genome editing) and/or variant screening (deep mutational scanning, base-editing). Experience with ex vivo pharmacology including model generation and optimization is strongly preferred. Excellent interpersonal skills with the ability to work in a matrixed environment, interacting with colleagues across functions including translational research, in vitro pharmacology, and drug discovery. Ability to interface with computational biologists and AI/ML experts to deploy appropriate analyses methodologies is required. An ability to mine large-scale genetic screen datasets using desktop tools/interfaces, AI integration, and public databases (CBIO, DepMap, TCGA, CCLE, Genepattern etc.) for target hypothesis generation is strongly desired. Proficiency in utilizing software such as Benchling, GraphPad, FlowJo, Microsoft Office, Spotfire, JIRA, Confluence etc. for experimental design, data analyses, tracking, and figure generation is highly desired. Additional Qualifications/Responsibilities Experience = Basic Qualifications: Bachelor's Degree 8+ years of academic and/or industry experience Or Master's Degree 6+ years of academic and/or industry experience Or Ph.D. or equivalent advanced degree in the Life Sciences 4+ years of academic and/or industry experience Preferred Qualifications: PhD with 4+ years of academic/industry experience in Oncology, with background in cancer immunology and/or exploration of tumor extrinsic mechanisms is strongly preferred. Experienced in the design and development of cell-based viability and reporter assays using various technology platforms, especially gene perturbation to assess viability, imaging, and signaling pathway phenotypes in organoid or tumoroid, and 2D cultures. Experience developing molecular biology assays, cell culture, and analyses of protein and DNA/RNA samples using a variety of methodologies including but not limited to: vector cloning, flow cytometry, RNAi, CRISPR-Cas, Cas activity assays (reporter and genomics readouts), qPCR, ex-vivo culturing, co-culture assays, functional and imaging-based readouts, lentiviral production and transduction, electroporation. Effectively troubleshooting skills when optimizing assays and when developing innovative methodologies. Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work. Ability to summarize and interpret scientific data in a clear, concise, and accurate manner. Excellent oral and written communication skills. Ability to communicate and discuss data with peers and supervisors. Ability to work alongside colleagues in a team environment. Exceptional organizational skills and meticulous attention to detail. Strong problem-solving skills and understanding of relevant scientific principles. #J-18808-Ljbffr National Guard Employment Network

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